There are a tremendous number of online resources out there meeting the call to help people in Southeast Asia and Eastern Africa. One of the better, and least denominational, is Network for Good. [Addition: This CNN page is also excellent]
From everything I’ve (sadly) heard over the past few days, nothing will help people more than plain old cash money. The organizations involved there simply need funds to keep supplies and food moving. I am donating to American Jewish World Service but it matters not.
Giving online, unlike sending a check or volunteering, still feels strange to me. The disconnect between the button clicked and the recipient helped is all too wide. But from the reports, it may be that donating on the Web may be the fastest route to those overwhelmed by tragedy.